Sam took a train from Buffalo at 12:30 A.M . and arrived at Ann Arbor, Mich. at 10 A.M. Sam wrote from Ann Arbor to Livy:
"...went straight to bed, declining President Angel’s [Buffalo University] invitation to dinner & meet ex-President Hayes’s wife & others at 6 this evening. It will be a long time before I sample anybody’s hospitality again. I have been asleep two hours, & shall resume it right off. I find no letters here—hope for some before we get away. I love you sweetheart "[MTP].
"The students generally, of whom the audience was largely composed, abandoned themselves to the most thunderous laughter every time Twain appeared on the stage; staid members of the University Faculty, who always maintained a twenty degrees below zero countenance in the classroom, laughed till they were out of breath; law professors, wrapped up in ponderous legal volumes, and who have not been known to smile in twenty-one years, fairly rolled off their seats from laughter at every point Twain made. Even a couple of Japanese students, who, although having a fair command of English, could not readily see the incongruities of Twain's remarks, felt in duty bound to join in the general feeling, and undoubtedly did their best, although several times they broke forth in the wrong place to the astonishment of those about them." The Northwestern 12-19-1884, Page 2; Evanston, Illinois
Railroads: Cleveland and Toledo, Cleveland, Painesville and Ashtabula, Detroit, Monroe and Toledo, Dayton and Michigan, Michigan Central
It is possible Sam took the Michigan Central Railroad along Lake Erie's northern shore.