In 1856 a new charter was obtained under the name of the Erie & Pittsburgh Railroad. In 1859 the track was completed through Crawford County to Jamestown, which remained the terminus from the north until 1864. Work was also progressing from the direction of New Castle. The first freight train arrived at Sharon from the south October 11, 1863, and the first passenger train the 4th of the following January. The line was finished through Mercer County during 1864, and the company advertised to run regular trains from Erie to New Castle after October 31, 1864. This road enters the county at Jamestown and passes down the Shenango Valley, tapping the towns of Greenville, Shenango, Transfer, Clarksville, Sharpsville, Sharon, Wheatland and West Middlesex in its route.

Railroads  From the History of Mercer County, 1888

The railroad was leased as of April 1, 1870, by the Pennsylvania Railroad.