LaSalle was named in honor of the early French explorer, Robert de LaSalle.

The Illinois and Michigan Canal was first thought up by French explorer, Louis Joliet. Much later, when Illinois became a state, the idea of a canal connecting Lake Michigan to the Illinois River was supported by many, including Abraham Lincoln. The 96 miles long canal was finally constructed between 1836 and 1848. Upon its completion, Chicago became the eastern terminus and LaSalle became the western terminus. LaSalle boomed as a transshipment point from canal boats coming from Chicago to steamboats going to St. Louis and New Orleans. It became a place where Northern and Southern culture met.

It is difficult to imagine the level of frenzied activity that once took place at locks 14 and 15, where the canal boat basin and the steamboat basins were located.  Steamboats from New Orleans unloaded molasses, sugar, coffee, and fresh oranges and lemons. Canal boats from Chicago brought lumber, stoves, wagons, and the latest clothing styles from the east. Local farmers hauled corn and wheat to be shipped to Chicago and points east. Passengers hustled to make connections to canal boats bound for Chicago or steamboats headed to St. Louis and beyond. Hotels and other services were available to travelers. Many stores grew catering to canal trade.

https://en.wikipedia.org/wiki/LaSalle,_Illinois