On March 16, 1844, the Old Colony Railroad Corporation was formed to provide a rail connection between Boston and Plymouth. Construction of the line began in South Boston in June 1844 and the 36.8-mile (59.2 km) line opened to Plymouth on November 10, 1845. The extension from South Boston to the newly completed Kneeland Street Station in Boston opened on June 19, 1847. Kneeland Street also served as the headquarters for the OC until the 1893 consolidation.

This is the Google Earth location for Kneeland St.  Precise location for the station is unknown.