Twain and Cable played at the Grand Opera House in Syracuse but it was not at the Wieting Opera House. The attached clippings, provided me by Kimberly Kleinhans, librarian, Local History/Genealogy, Onondaga County Public Library, describe the offerings at both venues.
By the late 1890s, the three theatres in Downtown Syracuse each had their own specialty. The Wieting Opera House became the house of stars in "touring combinations" while the Grand evolved into a vaudeville house and the Bastable, also in Clinton Square, featured stock companies and melodramas and was called the "house of 10-20-30 cent shows." At one point, the Shubert brothers managed all three facilities.
Today the side is occupied by the Atrium, a hotel and office-convention center. http://en.wikipedia.org/wiki/Clinton_Square