USS Quaker City was a heavy, 1,428 long tons (1,451 t) sidewheel steamship leased by the Union Navy at the start of the American Civil War. She was subsequently purchased by the navy, outfitted with a powerful 20-pounder long rifle, and assigned to help enforce the Union blockade of the ports of the Confederate States of America.
After the war, Quaker City was decommissioned at the Philadelphia Navy Yard on 18 May and sold at auction there on 20 June. Redocumented on 11 August, Quaker City then served American commerce under U.S. registry. In 1867, she was chartered to carry a group of American travelers on a "package tour" of France, Italy, Greece, Turkey, the "Holy Land", and Egypt, departing 8 June from New York City. Mark Twain was a member of the tour group, sponsored by the newspaper The Daily Alta California, and his humorous letters about the trip became his best-selling book The Innocents Abroad. The steamer was sold and renamed Columbia in 1869; later that year she was acquired by the Haitian Navy and renamed Mont Organisé. Sold again in February 1871, she was renamed République, but was lost at sea off Bermuda later in that month. She was on a voyage from "Le Marc" to New York.