The amphitheatre was built near the Porta Ticinese ("Ticino Gate") in the 2nd-3rd centuries AD, when Mediolanum grew as economical and political importance while Rome declined. It remained in use until the city was one of the capitals of the Western Roman Empire (4th or 5th centuries). Later it was abandoned after Christianism imposed the end to arena games, but also as, in the wake of the imperial crisis, animals to be used in the amphitheatre were no longer imported.