November – John Marshall Clemens chaired a citizens’ committee to promote a macadamized road between Hannibal and St. Joseph, Mo. [Wecter 110].
Henry La Cossitt, new to Hannibal, established the Democratic Gazette [Wecter 201]. Note: Wecter surmises that Sam Clemens was briefly an apprentice for the Gazette.
October 16 Friday – James Clemens, Jr. leased the Hill Street house to Orion Clemens for a period of 25 years at a rental of $28 per year [Hannibal Courier-Post, Mar. 6, 1935 p10b].
September 10 Thursday – John Marshall Clemens wrote to Buffum & Co., in New York concerning sale of the Tennessee Land. John had canceled the agency of Meredith & McCullough and gave “exclusive sale of my Tennessee lands for two years on the terms propose.—That you will be at the expense of agencies and advertising as in your letter mentioned; and will make sales as speedily and advantageously as possible” [MTBus 11]. Note: The Tennessee Land created a rift between Sam and Orion in later years, and hung around the family’s neck until the 1880s.
August – Hannibal slave dealer William Beebe sued and gained a judgment against John Marshall Clemens for $126.50 stemming from debts for the store [Wecter 112].
Summer – Cholera claimed 30 lives in Hannibal. Many fled the town [Wecter 213].
March 14 Saturday – William P. Owsley, was acquitted of murdering Samuel Smarr by a Palmyra jury. [Wecter 108]. 
November 30 Sunday – Sam’s tenth birthday.
November 6 Thursday – Record of Jimmy Finn’s death [MTP].
Fall – In either 1844 or 1845, Sam left the dame school for a “good common school” on Center Street near the town square, taught by a middle-aged Irishman, William O. Cross [Powers, D. Waters 93].
August 25-26 Tuesday – The Philadelphia North America reported on Aug. 26, “Affray at Hannibal, Mo.”—a fight between Dr. Orville R. Grant and a man named Railey, who stabbed Grant with a spear attached to his cane. In his Dec. 2, 1906 A.D. Sam recalled the man’s name as Dr. Reyburn [AMT 2: 590].