The Lehigh and Susquehanna Railroad is a defunct railroad that operated in eastern Pennsylvania during the 19th and 20th centuries. The company was a subsidiary of the Lehigh Coal & Navigation Company (LC&N). For much of its lifetime, however, it was leased by the Central Railroad of New Jersey.
The company was founded in 1837 for the objective of transporting predominantly anthracite coal from the North Branch Division of the Pennsylvania Canal to the Lehigh Canal on the Lehigh River. The rail line was later extended to the confluence of the Lehigh and Delaware Rivers in Easton, Pennsylvania.
In 1976, the company was sold to Conrail.