The Indianapolis and Bellefontaine Railroad (I&B) was an American railroad founded in 1848. It changed its name to the Indianapolis, Pittsburgh and Cleveland Railroad in 1854. Its counterpart in Ohio was named the Bellefontaine and Indiana Railroad (B&I). The B&I ceased to exist as an independent company when it merged into the Bellefontaine Railway in September 1864. The IP&C merged into the Bellefontaine Railway in December 1864.
On May 16, 1868, the Bellefontaine Railway was merged with the Cleveland, Columbus, and Cincinnati Railroad to form the Cleveland, Columbus, Cincinnati and Indianapolis Railway.