The Cleveland, Columbus and Cincinnati Railroad (CC&C) was a railroad that ran from Cleveland to Columbus in the U.S. state of Ohio in the United States. Chartered in 1836, it was moribund for the first 10 years of its existence. Its charter was revived and amended in 1845, and construction on the line began in November 1847. Construction was completed and the line opened for regular business in February 1851. The CC&C absorbed a small bankrupt railroad in 1861, and in May 1868 merged with the Bellefontaine Railway to form the Cleveland, Columbus, Cincinnati and Indianapolis Railway.
Merged with the Bellefontaine in 1868 to form the Cleveland, Columbus, Cincinnati and Indianapolis Railroad.