- 1847: The New Albany and Salem Railroad (NA&S) is organized with James Brooks as president.
- 1854: The NA&S trackage stretches from the Ohio River (at New Albany) to Lake Michigan (at Michigan City).
- 1859: The overextended and struggling NA&S is renamed the Louisville, New Albany and Chicago Railroad (LNA&C).
- April 30, 1865: The LNA&C becomes one of twenty railroads to haul Abraham Lincoln's funeral train, its portion being from Lafayette to Michigan City, Indiana.
- 1873: The LNA&C Railroad is reorganized as the Louisville, New Albany and Chicago Railway.
- 1881: The LNA&C consolidates with the Chicago and Indianapolis Air Line Railway, and the trackage of the new division is soon extended to reach into its namesake cities.
- July 1, 1897: The LNA&C is reorganized as the Chicago, Indianapolis, and Louisville Railway.
Travel is fatal to prejudice, bigotry, and narrow-mindedness