The site of today’s Historic Hotel Bethlehem changed as well, for the Moravians replaced the First House of Bethlehem with a general store in 1794. In fact, this business would gradually morph into a gorgeous inn over the next three decades, becoming the “Golden Eagle Hotel” at the beginning of the 1820s. That incarnation of the Historic Hotel Bethlehem continued to operate unhindered right up until 1919, when the building began temporarily housing convalescing soldiers upon their return from the European battlefields of World War I.

The Clinton House, at High and Church streets, was favored by industrialists and visiting salesmen, many tied to the booming carpet/weaving industry.

The Clinton House opened in 1847, capped by a mansard roof. A separate grand hall, called Clinton Hall, which would later host Twain, was added to the property three years later. Eventually, the hall and hotel were connected. 

Clinton Hall became the center of the town's social world. There were balls, lectures, school events and military gatherings.

At the same site as the first hotel, Francis Cornwall Sherman built a new structure, breaking ground on May 1, 1860, and opening the new structure to guests on July 1, 1861.[3] The structure was designed by William W.

1888’s The Empire State: Its Industries and Trade provided a nice description of the history of the establishment:

The Langham, London, is one of the largest and best known traditional-style grand hotels in London, England. It is situated in the district of Marylebone on Langham Place and faces up Portland Place towards Regent's Park.

The tower named Swych Utrechtnl, part of the Amsterdam city walls and defence system. It was part of the Kloveniersdoelen, the gathering and shooting place for the city militia/guard known as "kloveniers". Doelen means "targets" in Dutch. The companies of kloveniers were armed with an early type of musket then sometimes called in Dutch "klover", from the French couleuvrine, hence the name "kloveniers".

In 1860 the construction of the Hotel Grand Bretagne was in progress. The grand opening was in 1873. The luxury hotel had available 170 beds and was glamorously furnished. It offered every at hat time imaginable comfort to the guests. For example, there was a hydropower operated elevator. The technology for this lift was placed in a tower which is to date standing on the promenade.

In 1770 Mme Coutterand opened the first tourist hotel - l'Hotel d'Angleterre (the 'English Hotel') as English visitors outnumbered other nationals even though the journey took nine days. Since then the region has been inspirational to sporting enthusiasts, mountaineers, painters, writers such as Byron and Shelley, and those seeking inspiration or a change of pace in their lives. 

History of Chamonix

Geographic Location unknown

The Rigi Kulm Hotel is located immediately below the 1,798 metres (5,899 ft) summit of Mount Rigi in the Alps in the canton of Schwyz, Switzerland, about ten miles south of Zurich and eight miles east of Lucerne. Opened in 1816, it can only be reached on foot or via the Vitznau–Rigi or Arth–Rigi railways. It is said that 125 named peaks and thirteen lakes are visible from the hotel.

Noted in Bædeker as near Cassel's station (the mapped location).  

During its history of nearly four centuries, the Hôtel de l'Ecu de Genève, which no longer exists, had four different locations. Originally established on the side of the rue de la Rivière (the current rue de la Confédération), it was moved for the first time to the south front of the rue du Rhône, then occupied a house on the banks of the river and, finally, the plot neighbour, located near the Place du Rhône. The first mention of the hotel dates back to 1560. Ref: The monuments of art and history of the canton of Geneva. Volume I - Geneva on the water.

The Beau-Rivage Palace is a historical luxury five-star hotel in Lausanne, Switzerland. It is located in Ouchy, on the shores of Lake Léman.

The hotel opened in 1861 and the current main building was constructed in Art Nouveau and neo-baroque style in 1908. It is registered in the Swiss Inventory of Cultural Property of National and Regional Significance.

The Beau-Rivage Palace is owned by Sandoz Family Foundation founders of Sandoz AG, now Novartis.

Murray Hill Hotel was a hotel situated at 112 Park Avenue in Murray Hill, Manhattan, New York City. Built in 1884, with 600 rooms and two courtyards, it was demolished in 1947. It was part of the Bowman-Biltmore Hotels chain.

The castle hotel in Heidelberg was from 1873 to 1964 intermittently a hotel . In a location-dominant location above the Hortus Palatinus of the Heidelberg Castle , it was once one of the best houses on the square, which accommodated numerous prominent guests. Even Empress Sissi , Richard Wagner and Mark Twain were guests here. After the end of the hotel business, the building served until 2000 as an international study center of the University of Heidelberg . Since 2009, a residential complex of apartment complexes has been built on the site of the building.

Shepheard's Hotel was the leading hotel in Cairo and one of the most celebrated hotels in the world from the middle of the 19th century until it was burned down in 1952 in the Cairo Fire. Five years after the original one was destroyed, a new hotel was built nearby and named the Shepheard Hotel.

Twain remarks that the gondola he rode in belonged to the Grand Hotel d' Europe, so I assume that is where he stayed while in Venice. I did not find a listing for this hotel on Google but I did find the Hotel Londra Palace of Venice operating in 1853.

From Notebooks and Journals Vol II:
The Kronprinz of Germany knows how to keep hotel, anyway.

The Crown Prince the best hotel I know.

Chickens the size of sparrows - perfect.
["Hamburg spring chickens" which he found "a shade superior to anything strictly earthly" adding that he could not "think of anything that could taste so good, unless it might be a cherubim."]

Parlor stove & mantel combined -- peat. Can't get it very warm.

“The Manitoba was one of Winnipeg’s show buildings,” according to a February 9, 1899, editorial in the Telegram. “Its imposing dimensions testified to the importance of the prairie capital, as well as the enterprise of the corporation which erected it; and the comfort and luxury which it afforded to the travelling public, predisposed strangers favourably towards the city and made Winnipeg a welcome stopping-off place in the itinerary of tourists.”

Young Men s Hall in the Biddle House Block was first used November 21 1861 It seated 1 500 and for many years was a popular place of resort Since 1875 it has been but little used for lectures

The history of detroit and michigan or the metropolis illustrated, Silas Farmer 1889

The Biddle House was once Detroit's most luxurious hotel, but, like much of the city, its lasting legacy is tied to the automobile.

The Hotel Schweizerhof Lucerne is a five-star hotel in Lucerne . It stands near the shore of Lake Lucerne at the Schweizerhofquai . The hotel was built in 1845, has been steadily expanding over the years and has been owned by the Hauser family since 1861. It offers 101 rooms and suites, three restaurants, a bar, several function rooms and a wellness area. The hotel is one of the few in Switzerland that is a cultural asset of national importance and is a listed building. [2] The original architecture has remained largely preserved to this day.

Possible location.