The Boston and Lowell Railroad was a railroad that operated in Massachusetts in the United States. It was one of the first railroads in North America and the first major one in the state. The line later operated as part of the Boston and Maine Railroad's Southern Division.
The Salem and Lowell Railroad, chartered in 1848, was a railroad in Massachusetts that connected the towns of Peabody (near Salem) and Tewksbury (near Lowell). The company connected to other railroads at both ends to provide service to its two namesake cities - the Lowell and Lawrence Railroad at Tewksbury Junction, and the Essex Railroad at Peabody. Construction was completed in 1850, with train operations contracted to the Lowell and Lawrence until 1858, when the Boston and Lowell Railroad took over both companies. In 1887, the Boston and Maine Railroad took over the Boston and Lowell and became the new operator of the Salem and Lowell. The line gradually declined in importance from the start of the 20th century, and was progressively abandoned from 1925 onwards. The last trains ran on the route in 1980, and the remainder of the route formally abandoned in 1987. Parts of the right of way are now a rail-trail.