In 1863, he [Alexander Mitchell] organized the Milwaukee & St. Paul Railway (M&StP), which took over the La Crosse & Milwaukee, and in 1867 the M&StP absorbed the Milwaukee & Prairie du Chien, a company that earlier had succeeded the bankrupt Milwaukee & Mississippi. Mitchell’s network of railroads transformed Milwaukee into a hub for shipment of wheat from Wisconsin, Minnesota, and Iowa on such a scale that it rivaled Chicago. Encyclopedia of Milwaukee

It was at this juncture that Mr. John J. Mitchell, a warm friend and supporter of the Chicago and Alton interests, offered to build an independent road from Alton to East St. Louis, provided that the Chicago and Alton, on completion of the road, merge the franchises of the Alton and St. Louis charter, obtained in 1850, then owned and controlled by Mr. John J. Mitchell, with their own. The proposition was accepted, and during the winter of 1864 trains of the Chicago and Alton Railroad were running to East St. Louis, and terminating there on valuable depot grounds, obtained by Mr.

The Jeffersonville, Madison and Indianapolis Railroad (JM&I) was formed in 1866 as a merger between the Indianapolis and Madison Railroad and the Jeffersonville Railroad.

Wikipedia

Absorbed by the Pittsburgh, Cincinnati and St Louis (Panhandle) Railway in 1890.