The Pennsylvania Railroad had a total investment of $5,633,000 in the three companies, decided to consolidate the Panhandle, the Steubenville and Indiana and the Holliday’s Cove Rail Road into one company with a line from Pittsburgh to Columbus, a distance of 193 miles. It caused The Pittsburg, Cincinnati and St. Louis Railway Company to be organized on May 14, 1868, and the three predecessor companies were thus consolidated. The new consolidated company continued to be known colloquially as the “Panhandle”, by which name it and its successors will hereafter be frequently referred to.

The Sandusky City & Indiana Railroad Company, which was chartered February 28, 1851, built a road from Tiffin to Sandusky, via Clyde, and as this route was deemed more favorable than that via Bellevue, the Sandusky City & Indiana Company leased the road to the Mad River & Lake Erie Company for ninety-nine years, renewable perpetually, and has operated the road via Clyde, abandoning the other route.

The Little Miami joined the Cincinnati and Indiana Railroad in 1862 in building track along the riverfront in Cincinnati to link their two depots. The LMRR and the C&X together bought the Dayton, Xenia and Belpre Railroad in January 1865.

The Cincinnati, Hamilton and Dayton Railway (CH&D) was a railroad based in the U.S. state of Ohio that existed between its incorporation on March 2, 1846, and its acquisition by the Baltimore and Ohio Railroad in December 1917.