It was at this juncture that Mr. John J. Mitchell, a warm friend and supporter of the Chicago and Alton interests, offered to build an independent road from Alton to East St. Louis, provided that the Chicago and Alton, on completion of the road, merge the franchises of the Alton and St. Louis charter, obtained in 1850, then owned and controlled by Mr. John J. Mitchell, with their own. The proposition was accepted, and during the winter of 1864 trains of the Chicago and Alton Railroad were running to East St. Louis, and terminating there on valuable depot grounds, obtained by Mr.

The Jeffersonville, Madison and Indianapolis Railroad (JM&I) was formed in 1866 as a merger between the Indianapolis and Madison Railroad and the Jeffersonville Railroad.

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Absorbed by the Pittsburgh, Cincinnati and St Louis (Panhandle) Railway in 1890.

The Louisville and Nashville Railroad (reporting mark LN), commonly called the L&N, was a Class I railroad that operated freight and passenger services in the southeast United States.

The Baltimore and Ohio Railroad (reporting mark BO) was the first common carrier railroad and the oldest railroad in the United States with its first section opening in 1830. Merchants from Baltimore, which had benefited to some extent from the construction of the National Road early in the century, wanted to do business with settlers crossing the Appalachian Mountains.

• Chicago, Missouri and Western Railway 1987-1989
  • Illinois Central Gulf Railroad 1972-1987
    • Gulf, Mobile and Ohio Railroad 1947-1972
      • Alton Railroad 1931-1947 Subsidiary of Baltimore and Ohio Railroad

The Pittsfield and North Adams Railroad was a railroad based in northwestern Massachusetts. It was chartered in 1842 and was purchased by the Western Railroad of Massachusetts before construction was finished in 1846, then acquired by the Boston and Albany Railroad in 1870, only to face a gradual demise between the 1960s and 1990. It ran 18.539 mi (29.836 km) from North Adams Junction in Pittsfield to North Adams, where it connected to the Troy and Greenfield Railroad, an affiliate of the Fitchburg Railroad.

The New Haven and Northampton Railroad (founded as the New Haven and Northampton Company, also known as the Canal Line) was a railroad originally built alongside a canal between 1847 and 1850 in Connecticut.