The Sandusky City & Indiana Railroad Company, which was chartered February 28, 1851, built a road from Tiffin to Sandusky, via Clyde, and as this route was deemed more favorable than that via Bellevue, the Sandusky City & Indiana Company leased the road to the Mad River & Lake Erie Company for ninety-nine years, renewable perpetually, and has operated the road via Clyde, abandoning the other route.

The Little Miami joined the Cincinnati and Indiana Railroad in 1862 in building track along the riverfront in Cincinnati to link their two depots. The LMRR and the C&X together bought the Dayton, Xenia and Belpre Railroad in January 1865.

The Cincinnati, Hamilton and Dayton Railway (CH&D) was a railroad based in the U.S. state of Ohio that existed between its incorporation on March 2, 1846, and its acquisition by the Baltimore and Ohio Railroad in December 1917.

Indiana Central Railway Company (1851-1864)

Columbus and Indiana Central Railway Company (1864-1868)

Columbus, Chicago and Indiana Central Railway Company (1868-1968)

The New York, Chicago and St. Louis Railroad (reporting mark NKP), abbreviated NYC&St.L, was a railroad that operated in the mid-central United States.

The Terre Haute and Alton railroad built the first bridge over the Wabash  River in 1855.  The name changed to Terre Haute, Alton and St Louis Railroad in 1856 and changed again to St Louis, Alton and Terre Haute Railroad in 1862.  This existed until at least 1876 and was acquired by the Vanderbilts in the  mid 1880's.

The railroad was formed on June 30, 1889 by the merger of the Cleveland, Columbus, Cincinnati and Indianapolis Railway, the Cincinnati, Indianapolis, St. Louis and Chicago Railway and the Indianapolis and St. Louis Railway.