The Mississippi and Missouri Railroad (M&M Railroad) was the first railroad in Iowa.

The Toledo, Peoria & Western Railway was incorporated in Illinois on March 28, 1887, and consolidated the operation of the Toledo, Peoria & Warsaw Railway and the Logansport, Peoria & Burlington Railroad. The LP&B built from Galesburg to East Burlington, Illinois in 1855, and reached Gilman, Illinois in 1857 and Effner in 1859.

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Early in 1864, the Peoria and Oquawka Railroad had been changed to the Peoria and Burlington Railroad (March 8, 1864). Its construction had been completed (March 17, 1855) and it was operated under lease until June 24, 1864, when it became the property of Burlington, and on that date, by legislative act, the name of the road was changed from Chicago, Burlington and Quincy Rail Road Company to Chicago, Burlington & Quincy Railroad Company, under which the “Articles of Consolidations” became effective.

On September 25, 1857, the Chicago and Cincinnati Railroad was chartered in Indiana to build a line from Logansport northwest to Valparaiso. That line opened in 1861, connecting at Valparaiso with the Pittsburgh, Fort Wayne and Chicago Railway to Chicago.

The Norfolk and Western Railway (reporting mark NW),[1] commonly called the N&W, was a US class I railroad, formed by more than 200 railroad mergers between 1838 and 1982.

The Toledo and Illinois Railroad was chartered April 20, 1853, in Ohio to build from Toledo on Lake Erie west to the Indiana state line. The Lake Erie, Wabash and St.

The Peru & Indianapolis was incorporated January 19, 1846, to connect Indianapolis with the Wabash and Erie Canal at Peru. Construction began at Indianapolis in 1849 and service began over 21.42 miles of line to Noblesville on March 12, 1851. At the request of the Noblesville merchants, the railroad was built in 8th street to reduce the drayage cost for local freight. As the railroad built north it stimulated the location of new towns like Buena Vista, renamed Atlanta in 1881.

The Indianapolis and Bellefontaine Railroad (I&B) was an American railroad founded in 1848. It changed its name to the Indianapolis, Pittsburgh and Cleveland Railroad in 1854. Its counterpart in Ohio was named the Bellefontaine and Indiana Railroad (B&I).