The Columbus and Xenia Railroad was a railroad which connected the city of Columbus, with the town of Xenia in the state of Ohio in the United States. Construction began in October 1847, and the line opened in February 1850.

Leased to the Pittsburgh, Cincinnati and St Louis Company, November 1869.

Mr. H. J. Jewett, president of the Little Miami Railroad, spoke as follows in the Annual Report of the Little Miami Railroad for the year ended November 30, 1869:

The Cleveland and Pittsburgh Railroad was chartered in 1836, due to public support in building a railroad line between Cleveland and Pittsburgh. Construction of the line was completed in 1852, with additional branch lines to Akron, Ohio, and Wheeling, West Virginia. In 1871, the C&P was leased to the Pennsylvania Railroad for a 999 year lease, thus, giving the PRR access to Cleveland.

An anecdote found in Day By Day for March 4, 1906:

Mark Twain Got the Stateroom.

The Sunbury and Erie Railroad Company (also known as the Erie and Sunbury Railroad) was chartered by the Commonwealth of Pennsylvania in 1837, to build a rail line connecting towns between Sunbury and Erie, Pennsylvania.

The Philadelphia and Reading Railroad (P&R) was one of the first railroads in the United States. Along with the Little Schuylkill, a horse-drawn railroad in the Schuylkill River Valley, it formed the earliest components of what became the Reading Company. The P&R was constructed initially to haul anthracite coal from the mines of the Coal Region in Northeastern Pennsylvania to Philadelphia. The original P&R mainline extended south from the mining town of Pottsville to Reading and then to Philadelphia.

The East Pennsylvania Railroad was chartered on March 9, 1856, as the Reading and Lehigh Railroad, but was renamed in April 1857. It completed a line between Reading and Allentown on May 11, 1859. The opening of this line created a through route between Harrisburg and New York City. Philadelphia and Reading Railroad, predecessor of the Reading Company, leased the line in 1869. The East Pennsylvania continued to exist as a company, and would be merged along with the Reading into Conrail in 1976, as a result of the Reading's final bankruptcy