Twain devotes chapter 48 of Following the Equator to the "Great Mutiny". "It seems to be settled, now, that among the many causes from which the Great Mutiny sprang, the main one was the annexation of the kingdom of Oudh by the East India Company—characterized by Sir Henry Lawrence as "the most unrighteous act that was ever committed." That is the extent of his sympathy for the mutineers, most is expressed for the British.

"The Mutiny broke out at Meerut on the 10th of May, 1857, and fired a train of tremendous historical explosions. Nana Sahib's massacre of the surrendered garrison of Cawnpore occurred in June, and the long siege of Lucknow began. The military history of England is old and great, but I think it must be granted that the crushing of the Mutiny is the greatest chapter in it. The British were caught asleep and unprepared. They were a few thousands, swallowed up in an ocean of hostile populations. It would take months to inform England and get help, but they did not falter or stop to count the odds, but with English resolution and English devotion they took up their task, and went stubbornly on with it, through good fortune and bad, and fought the most unpromising fight that one may read of in fiction or out of it, and won it thoroughly."